臨床研究と生命倫理ジャーナル

概要

Epigenetics of Glioblastoma Multiforme

Rasime K

Aberrations in the epigenetic machinery of the genome may results the inactivation of critical genes and the epigenetic changes are important mechanisms in the evolution of malignancies that not only contributes to tumorigenesis but may also precede genetic changes. Several epigenetic mechanisms have been observed in glioblastomas including DNA hyper-methylation of genes, histone modifications including methylation and acetylation, nucleosomal rearrangement and dysregulation of noncoding RNA expression have been shown to play a critical role in the biology of glioblastomas and to contribute to the clinical outcome. This review examines the general role of epigenetic changes in the malignant process and focuses on the known epigenetic changes and development of new therapeutic strategies against these malignancies.