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Ex-Vivo Cardioprotective and Cytotoxic Screening of Fruits of Parmentiera cereifera Seem
Md. Reyad-ul-Ferdous, Tamara Towshin Alam, Md. Atiqul Islam, Md. Zahirul Islam Khan, Fariha Tasnim, Md Eshak Khan, Md Sharif Ullah and Tazmel Haque
In this present investigation, the fruits extract of Parmentiera cereifera were subjected to a comparative evaluation of the cardio-protective activities and Cytotoxic to brine shrimps (Artemia salina) as compared with standard streptokinase (SK) and Vincristine sulphate (VS). The crude methanolic (ME) extract, Hexane (HXSF) soluble fraction, carbon tetrachloride (CTCSF) soluble fraction, the Aqueous (AQSF) and chloroform (CSF) soluble fraction fruits of P. cereifera were subjected to these studies. In thrombolytic study, the fruits extract crude methanolic (ME) extract and Hexane (HXSF) soluble fraction were demonstrated mild to moderate (2.5 to 21.50%) thrombolytic activity in human blood specimen compared with standard streptokinase (SK) 66.77%. The fruits extracts were demonstrated (1.78 to 79.90) significant Cytotoxic to A. salina with LC50 values ranging from 6.07 to 7.83 µg/mL compared with standard Vincristine sulphate (VS, LC50 value 0.45 µg/mL).