アレルギーと治療のジャーナル

概要

Effect of Allergic Immune Response in the Modulation of Cancer Progression: Pivotal Role of the HIF1α/Th17

Belen Tirado-Rodriguez, Mayra Montecillo-Aguado, Mario Morales-Martinez and Sara Huerta-Yepez

There is an important  interest in finding whether people with allergic disorders, such as hay fever, asthma, and eczema, haver an increased or decreased risk of developing cancer(1). Although an association between allergic disorders and cancer risk is supported by epidemiologic studies, the exact nature of the association remains controversial. A promising discipline is the emerging field of AllergoOncology, which focuses on Th2 and IgEmediated immune responses in the cancer context, but this field has shown opposite results supported by two different theories and contradictory. In the correlation between allergy and cancer, exist different components, cellular and immunological, that could be involved on important way resulting in a pro-tumor or anti-tumor effect depending the cancer type and the immunological context. One molecule that may be involved is the hypoxiainducible factor 1 (HIF-1), a key oxygen sensor that is implicate in the tumor growth and play an important role in the differentiation T cell, in part, by the cytokine environment in the tumor microenvironment (EMT), one of these effects is to regulate the balance between regulatory T cell (Tregs) and T cells 17 (Th17) differentiation. In addition, is describing that Th17 cells are implicate directly in the severity of allergic diseases like allergic asthma. In the present review we going to highlight the evidence to suggest that the IL-17 overexpressed as well of the HIF1 high activation during allergic disease, induces the promotion of Th17 / IL17/Tregs balance and that results in a pro-tumor or anti-tumor response, depending of the cytokine environment.