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Development and Validation of Spectrophotometric and Pre-column Derivatization HPLC Method for Determination of Famotidine in Pharmaceuticals by Reaction with Sodium Nitroprusside; Application to Combined Tablets
Samah Abo El Abass, Mohamed I Walash and Fawzia Ibrahim
Spectrophotometric and HPLC methods for estimation of famotidine in pharmaceutical formulations through derivatization with sodium nitroprusside were developed. The spectrophotometric method is based on measuring the red color formed after the reaction with sodium nitroprusside at 498 nm. The formed product was further determined by HPLC method using C18 column, mobile phase composed of methanol and 0.05 M phosphate buffer (30:70, v/v) with apparent pH 4, The UV detection was at 498 nm. Both methods were linear covering concentrations of 20-500 μg/mL. The selectivity and the simplicity of the methods allow the successful estimation of famotidine in its pharmaceuticals and in its combined tablets with ibuprofen, domperidone, paracetamol and diclofenac without interferance.