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Development and Application of Rp-Hplc Method for Dissolution Study of Oral Formulations Containing Amlodipine Besylate
Harshal Ashok Pawar and Akanksha Yadav
In the present analytical study a rapid, robust and specific reversed-phase HPLC method has been developed and validated for quantitative estimation of amlodipine besylate in the dissolution study of oral films by direct injections of aqueous solutions. The study involved isocratic elution of amlodipine besylate in Zorbax® Eclipse XDB-C18 analytical column using buffer (0.7 % aqueous triethylamine adjusted to pH 3.0 with orthophosphoric acid) and methanol in the ratio of 40:60 (v/v). The aqueous solutions were analysed at a flow rate of 1.0 ml/min at 239 nm. The method presented linearity (r2= 0.999) in the concentration range 20-150 μg/ml. The result indicated good recoveries ranging from 98.06% to 99.22%. The method showed good precision with % Relative standard deviation value less than 2. All the validation parameters were within the acceptance range. The developed method can be successfully employed for in-vitro dissolution and routine analysis of formulations containing Amlodipine besylate.