糖尿病の症例報告

概要

Comparison of Antioxidative Effects of Biguanides and Sulfonylureas Monotherapy on Total Antioxidant Status in Newly-Diagnosed Patients with Type 2 Diabetes Mellitus

Siddique MAH, Begum A, Begum S, Khan MH, Saiedullah M, Haque A, Rahman MN and Ali L

Objective: The objective of this study was to compare total antioxidant status (TAS) in type 2 diabetic patients treated with Biguanides monotherapy and Sulfonylureas monotherapy in a tertiary health care center. Methods: Fifty subjects using Biguanides monotherapy and another 50 subjects using Sulfonylureas monotherapy for the management of type 2 DM were included. Their fasting plasma glucose (FPG), postprandial plasma glucose (PPG) concentrations were measured by spectrophotometric technique, percentages of glycated hemoglobin (HbA1c) was estimated by a modified high-performance liquid chromatography. TAS was determined by a modified ferric reducing ability of plasma (FRAP) assay. Results: The mean age of the total study subjects was 50 ± 9 years. Among them, 31% were male and 69% were female. Biguanides and sulfonylureas groups were matched for age, sex and glycemic status, but not matched for body mass index (BMI) and acute glycemic status (FPG and PPG). The mean value of TAS in subjects treated by Biguanides was 1386 ± 249 μmol/L and in subjects treated with sulfonylureas it was 1278 ± 275 μmol/L. Except PPG in the Biguanides treated group, acute or chronic glycemic status showed no significant relationship with TAS. Univariate linear regression analysis showed a significant association of TAS with Biguanides monotherapy (β=0.2039, p=0.042) but it disappeared when adjusted for glycemic status, age, sex, BMI, duration of diabetes mellitus and drug use (β=0.0455, p=0.6905). Conclusion: It may be concluded that there is no difference between Biguanides and Sulfonylureas regarding their effects on total antioxidant capacity in type 2 diabetic subjects.