法医学バイオメカニクスジャーナル

概要

Comparative Evaluation of Hypolipidemic Effects of Ethanolic Extract of Fruit of Piper chaba and Piper nigrum on Albino Rabbits

Sana Sarfaraz, Rahila Najam, Iqbal Azhar, Ghulam Sarwar

Background: One of the main causes of cardiovascular disease is increased cholesterol in the body. Unfortunately the trend of cardiovascular diseases is still very prevalent and no longer specific to adult population.

Objective: The present study was designed to evaluate the effect of ethanolic extract of fruit of Piper chaba and Piper nigrum on lipid profile and to evaluate which extract is more beneficial and could be helpful in treatment of cardiovascular diseases.

Methodology: The study was conducted on albino rabbits weighing 1000 gms-1600 gms. The animals were administered ethanolic extract of Piper chaba 150 mg/kg and Piper nigrum 250 mg/kg which was further diluted in Di methyl sulfoxide (DMSO) and dose was adjusted in ml based on weight of animals. After 7 days dosing animal’s blood was drawn and assessed for Cholestrol, HDL and LDL.

Results and Discussion: Our study showed that Ethanolic extract of Piper chaba possess significant hypolipidemic effects and lowers chlolestrol and LDL levels while shows significant effect on HDL levels too. Whereas Piper nigrum extract elevated cholesterol and HDL levels significantly and lowered LDL levels.

Conclusion: Piper chaba extract can be used in hyperlipidemia. Piper nigrum extract can be used to increase HDL and lower LDL. Further studies can be carried out to check effect on other organs for preferring the extracts in particular conditions.