ゲノミクスとプロテオミクスにおけるデータマイニングのジャーナル

概要

Commentary of Expertise on the Epigenetic Program during Intrauterine Development

Masato Kantake

Preterm infants reflect the influences of their early intrauterine environment at birth and are placed in a nonphysiological environment after birth. We have studied the epigenetics of the Glucocorticoid Receptor (GR) and the Insulin-like Growth Factor 1 (IGF1) gene, which are important in later life. Our studies indicate that these genes are mainly modified epigenetically after birth. The postnatal environment overlaps the prenatal condition, causing modification of these genes. Our studies may imply an adult disease onset model and a critical view on transgenerational inheritance in humans through epigenetic changes in gametes.