脳障害と治療

概要

Clinical, Pathological, and Hematological Study of Post-Injection Neuritis of the Sciatic Nerve by Alfatrim 24% Intramuscular Injection in Small Ruminants

Farhang Sasani, Javad Javanbakht, Feridon Nourmohammadzadeh, Mehdi Aghamohammad Hassan, Mehdi Rajabi Moghaddam and Aniseh Talebi

Medication therapy through improper injection techniques into a nerve may induce neuropathy, neuritis & injury. The aim is to analyse the pattern of this nerve lesion in clinical, pathological, and hematological parameters and also to study the outcome in a conservatively treated cohort. In this study, 40 cases of sheeps and goats about 3 years old, had received Alfatrim 24%, 1 cc per 20 kg BW in the rout of intramuscular each 12 hours for 3 days. The clinical signs included loss of function in nearly all of the hind limbs, with loss of skin sensation from the lateral surface of the tibial region of the hock joint to the distal parts. The foot is dragged in a manner of pulling his leg upward and forward in each gait by contraction of the quadriceps muscles which are innervated by the femoral nerve. In hematological examination, mature neutrophils of white and black goats were 73% and 61% respectively. However, normal value of mature neutrophils is 10-59% in goats. In addition, glucose and total protein were respectively 59 mg/dl and 1 g/dl in white goat’s CSF, whereas normal value of glucose and total protein in CSF are 71 mg/dl and 0.12-0.25 g/dl respectively. Furthermore, a sort of lameness took place by neuronal origin bilaterally following Alfatrim 24% injection intramuscularly, permanent occasionally, was a common consequence for intramuscular injection. Macroscopic lesions were swelling of sciatic nerve stem, submeningeal hemorrhage, fibrinopurulent inflammation & necrosis. In microscopic lesions neuronal fibers were normal (axon & myelin sheath), but there were fibrinous lymphoplasmacytic perineuritis, subepineuronal hemorrhage. Some of cases showed recovery 4 days after receiving Ibuprofen. Further studies on the effects of Alfatrim 24% on sciatic nerve in small ruminants need to be conducted. In particular, experimental studies will assist in the understanding of Alfatrim 24% and its relation to sciatic neuritis in small ruminants.