老年学と老年医学の研究

概要

Circulating Soluble Corin: A New Biomarker or Risk Factor for Age-Related Disorders

Shi Chen and Hao Peng

Natriuretic peptides have been associated with age-related disorders including cardiovascular disease and its metabolic risk factors such as hypertension, diabetes, obesity, and dyslipidemia. Recently, human corin, a type II transmembrane serine protease highly expressed in the heart, was found to play a physiological role in activation of natriuretic peptides. As a physiological activator of natriuretic peptides, corin might be associated with agerelated disorders.