血液疾患と輸血ジャーナル

概要

Blood Gases Regulate Cerebral Blood Flow

Emmanuel Andrè

The cerebrovascular flow response to a hypercapnia challenge can be calculated as cerebrovascular reactivity. The smooth muscle of the cerebral vasculature mediates the many facets of cerebral blood flow responses to combinations of blood gas challenges, which can be comprehensively explained by a simple mathematical model. During hypoxia, anemia, hypercapnia, and hypercapnia, the model accounts for blood flow. The model's key hypothesis is that these different problems, individually or in combination, operate through a common regulatory pathway: intracellular hydrogen ion concentration control.