生物学と医学

概要

Assessment of side-effects of administration of artemether in humans

AS Adekunle*, CO Falade, EO Agbedana, A Egbe

In animal in-vivo study, we have reported some significant changes such as reduced sperm counts, degeneration of seminiferous epithelium and interstitial leydig cells in the testicle. Therefore human study was designed to assess the effects of artemether on some biochemical parameters in individuals treated with artemether. Moderate and transient side effects were observed after administration. This implies that administration of artemether is still tolerated and the moderate side effects are not comparable with the debilitating effects of malaria infection it is meant to cure. Artemisinine is still a tolerable antimalaria drug with no major side effects on human.