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Antibacterial and Wound Healing Properties of Terminalia superba Engl. and Diels (Combretaceae) in Albino Wistar Rats
Dougnon TV, Klotoe JR, Bankole HS, Yaya Nadjo S, Fanou B and Loko F
The objective of this study was to evaluate the antibacterial and wound healing properties of the ethanol extract of Terminalia superba’s bark. In vitro tests were realized on it. Antibacterial activity and in vivo wound healing properties of the ethanol extract on infected lesions by reference strains of Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923 in Wistar rats were also evaluated. Thirty-two rats were divided into eight lots of four rats each. Two lots infected and treated with gentamicin, two control groups infected but untreated and a negative control group nor uninfected nor untreated were used. The last three lots were treated with the ethanol extract. Bacteriological tests on the reference strain of S. aureus ATCC 25923 and E. coli ATCC 25922 respectively showed a Minimum Inhibitive Concentration of 0.078 mg/ml and 10 mg/ml. The ethanol extract has a real healing potential and antibacterial activity against reference strains used. These antibacterial properties engage T. superba in the process of developing an improved traditional medicine.