臨床研究と生命倫理ジャーナル

概要

An Investigation into Phenomena of Vitamin D Status and its Association with Different Bio-Chemical Parameters: Pakistani Population Based Study

Sajid Hussain, Aqsa Akram, Rubaida Mehmood, Rehana Mumtaz

Background: Vitamin D deficiency is related to substandard health. The frequency of vitamin D deficiency may be rising, however populace based patterns are uncertain.

Objective: This study was conducted to investigate the status of vitamin D level and its association with biochemical parameters like Uric Acid, LDH, ALP, SGPT, SGOT, total bilirubin, urea, creatinine, calcium, cholesterol, triglycerides, LDL, HDL, sugar in our healthy population.

Materials and method: The study was the analytically observational. A total of 271 healthy subjects was randomly included (male and female) that came to examine the basic medical checkup in MINAR cancer hospital. Biochemistry parameters were analyzed on Chemistry Analyzer by Merck. The enhanced chemiluminescent immunometeric technique was applied to measure vitamin D level in the subjects.

Results: Vitamin D deficiency was investigated more in females (84.8%) as compared to males (62.8%) with significant variation (p=0.000) and in age group 1-26 years as compared to other age groups with significant variation (p=0.008). The weak negative correlation of vitamin D level with uric acid (p=0.031, r=-0.156) in the whole population was observed. No significant correlation was found between vitamin D level and other biochemical parameters ALP, SGPT, SGOT, total bilirubin, cholesterol, triglyceride, LDL, HDL, creatinine, urea, sugar, LDH.

Conclusion: The deficiency of vitamin D level was high in female (84.8%) in gender and 1-26 years (82%) in age groups of southern Punjab inhabitants. Significant week negative correlation of vitamin D level with uric acid was also investigated.