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概要

A Novel Stability-Indicating Method for the Simultaneous Estimation of Saxagliptin and Dapagliflozin in Rat Serum by Using UV Spectroscopy

Raveendra BG, KumarRA, Shaheen SD, Greeshma A, Satyanarayana M, Manikanta RSHT and Syam CPB

A new approach developed for stability-indicating, simultaneous estimation of Saxagliptin and Dapagliflozin in rat serum by using UV spectroscopy. Saxagliptin detection wave length was at 222 nm with water is solvent and Dapagliflozin detection wave length was at 274 nm with phosphate buffer pH 6.8 is solvent. Both drugs are obeyed the beers-lamberts concentration range was founds to be 1-10 μg/mL. The present method was optimized and validated in spiked rat serum according to ICH guidelines. All validation parameters were found to be within the acceptable limits and stability-indicating studies were conducted under different conditions founds in negligible. The present method was simple and sensitive; it was successfully adopted for the simultaneous estimation of Saxagliptin and Dapagliflozin in rat serum samples by using UV spectroscopy.

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