微生物および生化学技術ジャーナル

概要

A Novel Approach to Combat Acquired Multiple Resistance in Escherichia coli by using EDTA as Efflux Pump Inhibitor

Manu Chaudhary, Shailesh Kumar and Anurag Payasi

Escherichia coli is one of the leading pathogen responsible for severe ICU infections and have evolved a variety of strategies to resist antibiotics. A single resistance mechanism may diminish susceptibility to several therapeutic drugs allowing the survival of bacteria in their niches. Among the various resistance mechanisms, antibiotic removal from the bacterial cells by efflux pumps are most common. There are a number of reports indicating antibiotic resistance because of efflux pump in bacteria is increasing significantly. Therefore, antibiotic efflux pumps are thought of as attractive therapeutic targets, where their inhibition can restore antibiotic activity.