幹細胞研究と治療のジャーナル

概要

A Mini-Review: MicroRNA in Tendon Injuries

Jia Guo, Jin-fang Zhang, Gang Li and Kai-ming Chan

Tendon injury is a difficult clinical problem. Till now, the basic cell biology of tendons is still not fully understood and the management of tendon injury poses a considerable challenge for clinicians. Endogenous microRNAs are short noncoding RNA molecules which can negatively regulate gene expression at the post-transcriptional level. The regulatory role of miRNA has well been studied in many diseases, however the significance of miRNAs in tendon injuries remains elusive. This review summarized the miRNAs related to the pathogenesis of tendinopathy and tendon injuries and highlighted their clinical potential, which may bring new insights into developing a novel advanced strategy toward tendon injury treatment.